In-hospital Stellate Ganglion Block for Arrhythmic Storm

Recruiting now

Conditions studied: Arrhythmic Storm, Electrical Storm, Ventricular Fibrillation, Ventricular Tachycardia

In brief

Arrhythmic storm is a real emergency and its treatment could be challenging. Antiarrhythmic drugs are few and often ineffective. Neuromodulation has been grown in evidences but no large multicentric studies are present in literature about safety and effectiveness of Percutaneous Stellate Ganglion Block (PSGB). Patients with an electrical storm refractory to at least one antiarrhythmic drug will receive PSGB and will be enrolled in the present study. The number of defibrillations before and after the treatment will be compared, complications will be annotated.

Key facts

Study ID

NCT05720936

Run by

Fondazione IRCCS Policlinico San Matteo di Pavia

People needed

500

Starts

2017-11-07

Expected to finish

2028-12-31

Last updated by the study team

2025-06-08

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age ≥ 18 years,
• presence of arrhythmic storm defined as more than three sustained ventricular arrhythmias in 24 hours refractory to the standard medical treatment.

You may not qualify if…

• A previous history of cardiac sympathicectomy
• Having a neck judged unsuitable for the procedure (previous neck surgery, previous burns, presence of large scars, thyroid goiter)
• Both the two approaches present in literature and commonly used for this technique are allowed for the study:
• The "anatomical" approach which consist in the identification of the Chassaignac's tubercle that represents the point of needle insertion
• The "echo-guided" approach Regardless to the approach (anatomical or echo-guided) the doctor will be able to choose, according to the clinical characteristics of the patients, whether to perform a single shot injection of anesthetic or a continuous infusion of anesthetic. In the second case a catheter will be left in place and connected to an infusion pump.

Where it is running

• A.O. SS. Antonio e Biagio e Cesare Arrigo di Alessandria. — Alessandria, AL, Italy (enrolling)
• Ospedale di Bentivoglio — Bentivoglio, BO, Italy (enrolling)
• Ospedale Maggiore di Bologna — Bologna, BO, Italy (enrolling)
• Cardiology Department, Fondazione IRCCS Policlinico San Matteo — Pavia, PV, Italy (enrolling)
• Ospedale Civile — Voghera, PV, Italy (enrolling)
• Ospedale Mater Salutis — Legnago, VR, Italy (enrolling)
• A.O.U. delle Marche, Ospedali Riuniti — Ancona, Italy (enrolling)
• Ospedale Cardinal Massaia — Asti, Italy (enrolling)
• Policlinico S. Orsola-Malpighi, IRCCS A.O.U. Bologna — Bologna, Italy (enrolling)
• P.O. "San Michele" dell'ARNAS "G. Brotzu" di Cagliari — Cagliari, Italy (enrolling)
• Istituto clinico Humanitas Mater Domini di Castellanza — Castellanza, Italy (enrolling)
• Ospedale Maggiore — Crema, Italy (enrolling)
• Ospedale San Biagio di Domodossola — Domodossola, Italy (enrolling)
• Ospedale S. Maria Annunziata — Florence, Italy (enrolling)
• P.O. Santa Maria Nuova e Palagi — Florence, Italy (enrolling)
• Ospedale Misericordia di Grosseto. — Grosseto, Italy (enrolling)
• Ospedale di Gubbio-Gualdo Tadino, USL Umbria 1 — Gubbio, Italy (enrolling)
• Ospedale Civile di Ivrea — Ivrea, Italy (enrolling)
• Ospedale Alessandro Manzoni — Lecco, Italy (enrolling)
• Azienda USL Toscana Nord Ovest, Presidio di Livorno — Livorno, Italy (enrolling)
• A.O.U. Policlinico "G. Martino" di Messina. — Messina, Italy (enrolling)
• ASST Santi Paolo e Carlo — Milan, Italy (enrolling)
• IRCCS Ospedale San Raffaele — Milan, Italy (enrolling)
• Istituto Auxologico Italiano — Milan, Italy (enrolling)
• ASST Grande Ospedale Metropolitano Niguarda di Milano — Milan, Italy (enrolling)

Full record on ClinicalTrials.gov

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