Post Splenectomy Infections After Surgery for Peritoneal Malignancies (OPSI)

Recruiting now

Conditions studied: Infection;Post Surg Procedure, Peritoneal Cancer

In brief

The spleen is involved in maintaining immunity and plays an important role in the elimination of encapsulated bacteria and parasites. Patients who undergo splenectomy in conjunction with complete CRS for peritoneal malignancy are at risk of overwhelming post-splenectomy infections post-operatively. These patients are therefore administered vaccinations to lower the risk of infections but as they do not completely eliminate the risk, patients are also prescribed prophylactic antibiotics without clear evidence that they are useful in preventing OPSI. The use of prophylactic antibiotics is not without risk with potential short and long-term risks including resistance, interaction with other medication, clostridium difficile infections, fungal infections, other changes to the microbiome and cost. This study will investigate the incidence of OPSI post splenectomy and assess compliance with prophylactic antibiotics. This is an observational study where consented patients will be telephoned at fixed time points which are 1,6,12 weekly and 6 monthly for a period of five years post-operatively. As part of routine care patients will be telephoned by the clinical nurse specialist at weeks 1,6 and 12. In addition to this the research nurse will telephone the patient 6 monthly for a period of 5 years and complete a questionnaire. The research nurse will complete the questionnaire during each telephone call and this should not take more than 20 minutes. At the start of the telephone call, consent will be confirmed each time and the research nurse will check that the patient is still happy to participate before going ahead.

Key facts

Study ID

NCT05718726

Run by

Hampshire Hospitals NHS Foundation Trust

People needed

300

Starts

2021-03-25

Expected to finish

2031-02-01

Last updated by the study team

2024-11-27

Who can join

Age: 18 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged >18 and <80 years Patients capable of providing informed consent Patients who have a splenectomy in conjunction with complete cytoreductive surgery (CRS) for any pathology

You may not qualify if…

• Patients who are <18 and >80 Patients who do not provide informed consent Patients on immunosuppression therapy

Where it is running

• The Peritoneal Malignancy Institute, Hampshire Hospitals NHS Foundation Trust — Basingstoke, Hampshire, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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