Ultra-protective Ventilation Monitored by Electrical Impedance Tomography in Patients With Severe Acute Respiratory Distress Syndrome on Veno-venous ECMO
Recruiting now · Not applicable
Conditions studied: Severe ARDS
In brief
For ECMO supported patients with severe ARDS (acute respiratory distress syndrome), usual care include use of "ultraprotective" mechanical ventilation with tidal volume and pressure reductions that might ultimately enhance lung protection of patients with ARDS. Although very low tidal might also cause pulmonary derecruitment. The aim of this study is to monitor effects of very low tidal volume on regression of overdistension and derecruitment using electrical impedance tomography. Secondary aim is to describe the evolution of the optimal PEEP (Positive End Expiratory Pressure) during the decrease of the tidal volume
Key facts
- Study ID
- NCT05717218
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 50
- Starts
- 2023-03-11
- Expected to finish
- 2027-05-11
- Last updated by the study team
- 2025-05-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- aged ≥ 18 years
- patient with ARDS on venovenous (VV)-ECMO
- Written informed consent
- patient affiliated to a social security scheme
You may not qualify if…
- Pregnancy
- Adult patient subject to a legal protection measure (tutor, curator, etc.)
- Patients with a pacemaker, automatic implantable cardioverter defibrillator,
- contraindications to thoracic belt placement (e.g., thoracic or spinal cord trauma, recent thoracic surgery)
- undrained pneumothorax, bronchopleural fistula
- hemodynamic instability (i.e., use of intravenous fluids of more than 10 mL/kg or vasopressors 2 mg/h of norepinephrine or 0.5 mg/h of epinephrine)
Where it is running
- Service de médecine intensive - réanimation Hopital Pitié Salpêtrière — Paris, France (enrolling)
Full record on ClinicalTrials.gov
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