meChANisms and sAfety of SGLT2 Inhibition in peRitoneal dialYsis

Recruiting now · Phase 3

Conditions studied: Peritoneal Dialysis Complication, End Stage Kidney Disease, Sodium-glucose Co-transporter-2 Inhibitors, Kidney Dysfunction, Residual Kidney Function

In brief

The primary aim of this study is to determine the safety and mechanisms of SGLT2 inhibition in individuals on peritoneal dialysis (PD) with residual kidney function (RKF).

Key facts

Study ID

NCT05715814

Run by

University Health Network, Toronto

People needed

20

Starts

2024-09-01

Expected to finish

2027-12-01

Last updated by the study team

2026-05-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed and dated written informed consent.
• Patients aged ≥18 years on PD with RKF defined as at least 250 cc of urine output per day (assessed via 24-hour urine collection) and a minimum measured GFR of 2 ml/min/1.73m2, as measured at least once in the last 3 months.
• Stable PD prescription, as determined by investigators.
• Stable dose of RAAS blockade if on a medication within this class for the last 30 days.

You may not qualify if…

• Type 1 diabetes.
• Recent (in the 30 days prior to screening) acute coronary syndrome or cerebrovascular event.
• PD peritonitis within 30 days of screening.
• History of organ transplant, including pancreas, pancreatic islet cells or kidney transplant.
• Planned surgery/procedures or radiologic investigations requiring contrast during the trial.
• Pregnant, planning to become pregnant, or nursing an infant during the study period
• History of any DKA event
• Blood dyscrasias or any disorders causing hemolysis or unstable red blood cells (e.g., malaria, babesiosis, hemolytic anemia) at screening.
• Women who are pregnant, nursing, or who plan to become pregnant whilst in the trial.
• Alcohol or drug abuse within the 3 months prior to screening that would interfere with trial participation based on Investigator's judgement.
• Use of SGLT2 inhibitor within 30 days prior to screening.
• Intake of an investigational drug in another trial within 30 days prior to screening.
• Patient not able to understand and comply with study requirements, based on Investigator's judgment.
• Any other clinical condition that, based on Investigator's judgement, would jeopardize patient safety during trial participation or would affect the study outcome (e.g. immunocompromised patients, active malignancy, patients who might be at higher risk of developing genital or mycotic infections, patients with chronic viral infections, uncontrolled hypertension, cardiorenal and/or hepatorenal syndrome, severe hepatic impairments etc.).

Where it is running

• Toronto General Hospital — Toronto, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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