Aortic Stiffness in Patients With Genetic Aortopathies

Recruiting now

Conditions studied: Rare Diseases, Aortic Stiffness, Connective Tissue Defect

In brief

The goal of this observational study is to study arterial stiffness in patients with thoracic ascending aortic aneurysms (TAA), either syndromic or non-syndromic. The main questions it aims to answer are: * Stratification of aortic risk based on arterial stiffness; Compare measurements with morphological and haemodynamic features of the ascending thoracic aorta. Participants will be asked to undergo non-invasive evaluation of blood pressure and arterial stiffness.

Key facts

Study ID

NCT05715203

Run by

IRCCS Policlinico S. Donato

People needed

250

Starts

2023-02-15

Expected to finish

2025-12-31

Last updated by the study team

2025-09-10

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with AAT, either syndromic or non syndromic;
• Signed informed consent

You may not qualify if…

• Patients with early menopause and/or osteoporosis, rheumatic heart disease and active malignant tumours;
• Patients with acute and chronic inflammatory conditions such as: chronic liver disease, chronic renal insufficiency and diseases affecting the thyroid system;
• Seropositivity to HIV, HCV, HBsAg and SARS-CoV-2;
• Pregnancy

Where it is running

• IRCCS Policlinico San Donato — San Donato Milanese, Lombardy, Italy (enrolling)

Full record on ClinicalTrials.gov

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