Effects of Beef Consumption on Skeletal Muscle Protein Homeostasis and Inflammatory Factors in Pre- and Postmenopausal Females

Completed · Not applicable

Conditions studied: Menopause Related Conditions

In brief

This will be a randomized study to determine if animal-based protein-rich food sources can stimulate greater muscle protein turnover and whole-body protein balance and reduce skeletal muscle inflammatory markers in postmenopausal women compared to vegetarian base protein-rich foods.

Key facts

Study ID

NCT05714462

Run by

University of Arkansas

People needed

65

Starts

2023-08-28

Expected to finish

2025-04-01

Last updated by the study team

2025-05-06

Who can join

Age: 35 and older, up to 65. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Postmenopausal women ages 50-65 (absence of menstruation for at least 12 months).
• Premenopausal women ages 35-45 (presence of normal monthly menstruation for the past 12 months).
• BMI of 20.0 - 34.9 kg/m2.
• COVID-19 negative and/or asymptomatic

You may not qualify if…

• Any substantial musculoskeletal injuries/diseases that have limited daily activities in the past month.
• Unable to stop the use of anti-inflammatory drugs for the week prior to and during study.
• Diagnosed metabolic or hormonal disease (i.e., renal, cardiovascular, thyroid, polycystic ovary syndrome, or type I/II diabetes mellitus).
• Currently pregnant.
• Gave birth or was lactating within previous 12 months.
• Undergone gastric bypass/bariatric surgery.
• Clinically significant weight gain or loss (>5% change) in the last 12 months.
• Consuming metabolism-altering drugs or medications (i.e., corticosteroids, stimulants, insulin, thyroid medication).
• Unable or unwilling to suspend anti-clotting medications including aspirin use for 5 days prior to Visit 4.
• Participating in >200 minutes/week of vigorous exercise and/or >4 days/week of resistance training.
• Unwilling to fast overnight.
• Surgical menopause.
• Having undergone hormone replacement therapy in the last 12 months.

Where it is running

• Center of Translational Research in Aging and Longevity — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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