Bleeding of Unknown Cause: a Swiss Case-control Study

Recruiting now

Conditions studied: Bleeding Disorder

In brief

The goal of this prospective cohort is to identified specific biological patterns in patients with a bleeding of unknown cause and to study the specific mechanisms of the bleeding disorder for each subset of patients.

Key facts

Study ID

NCT05713734

Run by

University Hospital, Geneva

People needed

400

Starts

2023-04-01

Expected to finish

2027-04-01

Last updated by the study team

2026-04-29

Who can join

Age: 16 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Man with ISTH BAT>3. If the calculated score includes a surgical bleeding, then two other items of the score should be >0
• Woman with ISTH BAT >5 points. If the calculated score includes a surgical or a postpartum bleeding, then two other items of the score should be >0

You may not qualify if…

• Ongoing pregnancy
• Intake of antithrombotic treatment or non-steroidal anti-inflammatory drugs for least 10 days at time of blood collection
• Intake of antifibrinolytic or blood product administration (factor concentrate, frozen fresh plasma, prothrombin complex concentrate) for least 14 days before blood collection
• Active cancer (defined as cancer diagnosis within the last five years or treatment within the two last years before study inclusion)
• Active autoimmune disease
• Active chronic inflammatory disease
• Severe liver disease (cirrhosis > Child A)
• Renal insufficiency stage 3
• Active or recent infection (within the last 30 days)
• Recent hospitalization (<3 months)
• Recent surgery (<3 months)
• Recent trauma requiring medical intervention (<3 months)

Where it is running

• Ospedale Regionale di Bellinzona — Bellinzona, Switzerland (enrolling)
• Inselspital - Universitätsspital Bern — Bern, Switzerland (enrolling)
• University Hospital — Geneva, Switzerland (enrolling)
• Centre Hospitalier Universitaire Vaudois — Lausanne, Switzerland (enrolling)
• Gruppo Ospedaliero Moncucco — Lugano, Switzerland (enrolling)
• Kantonsspital St.Gallen — Sankt Gallen, Switzerland (enrolling)
• USZ - Universitätsspital Zürich — Zurich, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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