Neuro-affective Response to Light in Depressed Adolescents and Young Adults
Recruiting now · Not applicable
Conditions studied: Depression in Adolescence, Depression in Adults
In brief
The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are: * Does acute exposure to blue light (vs red light) stabilize emotional brain function in depressed individuals? * Are stabilizing effects of blue light (vs red light) stronger for blue light in adolescents than young adults? Participants will complete: * A magnetic resonance imaging brain scan, in which we will examine the effect of blue versus red light on emotional brain function at rest and in response to rewards and losses. * A pupillometry test of sensitivity to blue vs red light * Clinical interviews and surveys * Screening measures for drug and alcohol use, MRI safety, and current pregnancy \[if relevant\] * Home sleep tracking with sleep diary and actigraphy for one week
Key facts
- Study ID
- NCT05712772
- Run by
- University of Pittsburgh
- People needed
- 80
- Starts
- 2023-06-14
- Expected to finish
- 2026-07-31
- Last updated by the study team
- 2025-08-11
Who can join
Age: 12 and older, up to 30. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Elevated Depressive Symptoms [PHQ9≥5 And (Item 1≥1 or Item 2≥1)]
- (If <18yr) Parent or guardian can attend the baseline clinical interview
You may not qualify if…
- Unable to read and write in English
- Intellectual disability.
- Left or mixed handedness
- Changes to psychotropic medication type or dosage in the past 2 months
- Lifetime bipolar disorder or schizophrenia, or substance/alcohol disorder in the past 3 months.
- Factors influencing light and color sensitivity (i.e., color-blindness, serious ophthalmological conditions, photo-sensitizing medication).
- Factors influencing the ability to maintain a stable sleep schedule (i.e., shift work, severe sleep disorders, extremely late or early sleep schedule).
- Severe medical illness, neurological disorders, or history of head trauma.
- Current pregnancy or nursing
- MRI contraindication (e.g., metals in the body, recent tattoo, claustrophobia)
- Positive alcohol or substance use screen at MRI visit
Where it is running
- Western Psychiatric Hospital — Pittsburgh, Pennsylvania, United States (enrolling)
Full record on ClinicalTrials.gov
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