Platelet-Directed Whole Blood Transfusion Strategy for Malaria

Recruiting now · Not applicable

Conditions studied: Severe Malaria, Thrombocytopenia

In brief

Open-label randomized controlled trial to test the effectiveness of whole blood transfusion for improving survival in children with severe malaria complicated by thrombocytopenia.

Key facts

Study ID

NCT05711485

Run by

Johns Hopkins Bloomberg School of Public Health

People needed

132

Starts

2024-02-24

Expected to finish

2028-05-31

Last updated by the study team

2025-10-09

Who can join

Age: 1 and older, up to 5. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age <5 years
• Platelet count ≤75,000/uL
• Hemoglobin >5 and ≤9 g/dL
• P. falciparum parasitemia ≥500 parasites/uL
• Diagnosis of severe malaria meeting World Health Organization (WHO) criteria
• Ability and willingness of the legal guardian to comply with study protocol for the duration of the study
• Residence within health clinic catchment area
• Signed informed consent obtained from the parent or legal guardian of the participant

You may not qualify if…

• Residence in foster care or children otherwise under government supervision
• Residence outside the hospital catchment area, or plan to leave the area
• Presence of any other condition or abnormality which, in the opinion of the investigator, would compromise the safety of the participant or the quality of the data
• Any contraindication to whole blood transfusion

Where it is running

• Tropical Diseases Research Centre — Ndola, Copperbelt, Zambia (enrolling)
• Johns Hopkins Bloomberg School of Public Health — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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