REALITY MONITORING AND DOPAMINE
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Neurosciences
In brief
Reality-monitoring characterizes the ability to determine whether information was perceived in the environment or only imagined . Impaired reality-monitoring abilities have been associated with hallucinations in patients with schizophrenia and patients with Parkinson's disease. The investigators hypothesize a link between dopaminergic (DA) transmission and reality-monitoring.
Key facts
- Study ID
- NCT05711082
- Run by
- Hôpital le Vinatier
- People needed
- 39
- Starts
- 2024-01-15
- Expected to finish
- 2027-02-28
- Last updated by the study team
- 2026-06-12
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy volunteers who have given their written informed consent
- Men and women from 18 to 45 years old
- Normal or corrected vision
- Being fluent in French or French for native language
- Being affiliated with health insurance
You may not qualify if…
- Healthy volunteers who have given their written informed consent
- Men and women from 18 to 45 years old
- Normal or corrected vision
- Being fluent in French or French for native language
- Being affiliated with health insurance
- Inadmissibility of the subject's consent or refusal
- Working-memory deficit (as controlled with MMSE score< 23)
- Any past or current psychiatric or somatic condition(as controlled with the Mini International Neuropsychiatric Interview, MINI)
- Any past or current neurological condition
- History of cranio-cerebral trauma, arterial hypotension or hypertension, cardiological or serious medical condition
- Abnormal potassium dosage (below 3.1 mmol/L or above 4.9 mmol/L)
- Anormal ECG
- History of schizophrenia or bipolar disorder in first-degree relatives
- Alcohol-drinking and caffeine intake at least during 24 hours before each session
- Drug therapy excepting contraceptives
- Cardiologic or severe medical conditio
- Pregnancy(checked with a pregnancy autotest), lactation, or insufficient contraceptive measure (precautionary measure)
- Consumption of recreational drugs during the last 6 months
- Known sensitivity to any of the study medication and their excipients
- Lactose intolerance
- Porphyria
- Hepatic insufficiency
Where it is running
- Centre Hospitalier le Vinatier — Bron, France (enrolling)
Full record on ClinicalTrials.gov
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