The SaVe Project-Sarcopenia and Vertigo in Aging Patients With Colorectal Cancer

Recruiting now · Not applicable

Conditions studied: Colorectal Cancer, Oncologic Complications, Comprehensive Geriatric Assessment, Vestibular Rehabilitation, Geriatric Oncology, Sarcopenia, Vertigo, Cancer, Rehabilitation, Exercise, Geriatric, Elderly, Frail, Older Adults, Chemotherapy, Chemotherapy-induced Peripheral Neuropathy, Resistance Training, Balance Training, Postural Stability, Pragmatic Trial, Personal Medicine, Individualised

In brief

The goal of this clinical trial is to learn about the cause of dizziness and decline in walking ability in in older adults ≥65 years during chemotherapy treatment for colorectal cancer. Another goal is to investigate if a comprehensive geriatric assessment and three months' specialized physical group-based exercise three times/week can counteract muscle weakness, vertigo, instability, impaired walking balance, and neuropathy

Key facts

Study ID

NCT05710809

Run by

Rigshospitalet, Denmark

People needed

150

Starts

2023-02-20

Expected to finish

2027-09-01

Last updated by the study team

2025-04-06

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meet the criteria of the oncological departments of receiving neoadjuvant, adjuvant or first line palliative chemotherapy for colorectal cancer
• ≥65 years of age at the time of signing the informed consent form
• Able to speak and read Danish, and to provide a signed informed consent form
• Have an Eastern Cooperative Oncology Group (ECOG) performance status score of ≤2

You may not qualify if…

• Chemotherapy treatment within two years and sequelae of neuropathy, or symptoms of dizziness or vertigo, or balance disturbance
• Severe physical disability that hinders physical exercise
• Dementia, psychotic disorders, or other cognitive diseases or conditions that hinder participation in a clinical exercise-based trial
• Inability to sign informed content
• Patients who have had a consultation in the geriatric outpatient clinic within the past six months

Where it is running

• Copenhagen University Hospital - Herlev and Gentofte Hospital — Herlev, Denmark (enrolling)
• Copenhagen University Hospital - Rigshospitalet — Copenhagen, Denmark

Full record on ClinicalTrials.gov

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