Phase II Cohort of Spinal Stereotactic Radiotherapy in Patients Using a MR LINAC

Recruiting now · Phase 2

Conditions studied: Spinal Disease

In brief

To learn whether giving spinal stereotactic radiosurgery (SRSS) that uses a more advanced imaging scan method called Magnetic Resonance imaging with a Linear Accelerator (MR-LINAC) during treatment will lead to improved responses to treatment and better quality of life. SRSS is radiation therapy given to the area around your spine.

Key facts

Study ID

NCT05709782

Run by

M.D. Anderson Cancer Center

People needed

40

Starts

2023-05-09

Expected to finish

2029-01-13

Last updated by the study team

2026-07-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years old
• Radiographically documented disease of the spine within 4 weeks of registration (candidates with or without epidural disease allowed)
• Candidate for spine SRS/SBRT as determined by treating Radiation Oncologist or Multidisciplinary Spine Conference review
• Maximum of 3 contiguous vertebral levels involved with metastasis in the spine to be irradiated allowed
• Diagnosis of cancer documented
• Motor strength ≥ 4 out of 5 in the extremity affected by the level of spinal disease planned for radiation
• Karnofsky Performance score (KPS) ≥ 40 or ECOG score ≤ 3

You may not qualify if…

• Patients with highly radiosensitive histologies likely to respond to conventional radiation therapy alone (ie lymphoma, multiple myeloma, etc)
• Patients who are unable to undergo MRI of the spine with contrast
• Patients who are pregnant

Where it is running

• M D Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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