Dietary Interventions During Living Kidney Donations

Recruiting now · Not applicable

Conditions studied: Living-Kidney Donors

In brief

Monocentre, non-randomized, non-blinded, open-label interventional study to identification of relevant changes in molecular biology in proteome, phosphoproteome, lipidome, epigenome and transcriptome in pretransplant kidney biopsy samples in patients preconditioned by different dietary regimes (fasting mimicking diet vs. ketogenic diet vs. dietary restriction of sulfur containing amino acids vs. control patients)

Key facts

Study ID

NCT05709600

Run by

University of Cologne

People needed

80

Starts

2023-02-01

Expected to finish

2027-06-30

Last updated by the study team

2026-04-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients > 18 years of age
• Planed living kidney transplantation (both donor and recipient are eligible)
• Written informed consent

You may not qualify if…

• Vegetarian lifestyle
• Body-Mass-Index (BMI) < 18.5 kg/m2
• Calorie-reduced diet within the preceding four weeks
• Underlying wasting syndrome
• Contraindication for enteral nutrition
• Known allergy to or intolerance of the ingredients of the diet used
• Pregnancy
• Breastfeeding
• Absence of safe contraceptive measures or non-occurrence of menopause (in women)
• Participation in other interventional trials

Where it is running

• Department II of Internal Medicine, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne — Cologne, Germany (enrolling)

Full record on ClinicalTrials.gov

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