Outcomes of Functional Substrate Mapping of Ventricular Tachycardia
Status unconfirmed
Conditions studied: Ventricular Tachycardia
In brief
The goal of this registry database is to demonstrate the safety and effectiveness of functional ventricular tachycardia (VT) ablation using SENSE protocol in patients with ischaemic VT. Mortality and the need for ICD therapies at 12 months post-ablation will be compared with propensity-matched controls undergoing substrate-based ablation alone.
Key facts
- Study ID
- NCT05708131
- Run by
- Mid and South Essex NHS Foundation Trust
- People needed
- 70
- Starts
- 2022-07-13
- Expected to finish
- 2024-12-01
- Last updated by the study team
- 2024-01-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- One of the following VT events (within the last 6 months) + Ejection Fraction <40%:
- A: ≥3 episodes of VT treated with anti-tachycardia pacing (ATP), at least one of which is symptomatic.
- B: ≥1 appropriate ICD shock. C: ≥3 VT episodes within 24 hr. D: Sustained VT below the detection rate of the ICD.
You may not qualify if…
- Contraindication to VT ablation
- Renal failure (CrCl < 15 mL/min)
- NYHA IV or CCS IV angina
- STEMI within 1 month
- CABG within 3 months
- PCI within 1 month
- Pregnant
- Life expectancy < 1 year
Where it is running
- Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
- Onassis Cardiac Surgery Center — Athens, Greece (enrolling)
- Virgen de las Nieves University Hospital — Granada, Spain (enrolling)
- Arrhythmia Unit, University Hospital Ramón y Cajal — Madrid, Spain (enrolling)
- Basildon University Hospital — Basildon, United Kingdom (enrolling)
- Royal Sussex County Hospital — Brighton, United Kingdom (enrolling)
- Royal Brompton & Harefield hospital — London, United Kingdom (enrolling)
- St Bartholomew's Hospital — London, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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