Cardiovascular Effects of Very Low Nicotine Content Cigarettes

Recruiting now · Early Phase 1

Conditions studied: Tobacco Use

In brief

The study is measuring Cardiovascular effects of very low nicotine content cigarettes on daily and non-daily smokers

Key facts

Study ID

NCT05707871

Run by

Wake Forest University Health Sciences

People needed

49

Starts

2023-04-04

Expected to finish

2026-12-01

Last updated by the study team

2025-10-03

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Self-reported cigarette smoking at least once in the past 30 days
• ≥21 years old
• Willingness to smoke research cigarettes or usual brand cigarettes during lab visit.
• Ability to speak, comprehend, and read English sufficiently to complete study procedures

You may not qualify if…

• Self-reported diagnosis of cardiovascular diseases like coronary artery disease, stroke, peripheral artery disease, cardiac arrhythmia, pulmonary embolism \& blood clots in legs and arm in the past 3 months
• Body temperature ≥ 100.4˙F
• Unstable health conditions interfering with electrocardiogram (ECG) measurements
• Self-reported diagnosis of hyperthyroidism or thyrotoxicosis
• Currently pregnant (as indicated by urine pregnancy test at the start of laboratory visit) or breastfeeding.
• Currently seeking treatment to quit smoking

Where it is running

• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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