Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease

Running, not enrolling

Conditions studied: Juvenile Huntington Disease, Juvenile-Onset Huntington Disease

In brief

The goal of this observational study is to learn about brain development in Juvenile-onset Huntington's Disease (JoHD). The main questions it aims to answer are: * Is brain development different in JoHD than Adult-onset Huntington's Disease (AoHD)? * Can reliable biomarkers for JoHD be found in brain structure and function? Participants will be asked to complete cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI. Data collected will be compared to populations who are at-risk for HD and who have been diagnosed with HD as adults.

Key facts

Study ID

NCT05707663

Run by

University of Iowa

People needed

37

Starts

2020-01-01

Expected to finish

2026-08-31

Last updated by the study team

2026-04-30

Who can join

Age: 4 and older, up to 30. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of JoHD
• Aged 4-30

You may not qualify if…

• Metal in body
• History of head trauma, brain tumor, seizures or epilepsy unrelated to JoHD
• History of major surgery or serious chronic medical conditions other than JoHD

Where it is running

• University of California Davis — Sacramento, California, United States
• University of Iowa Hospitals and Clinics, Department of Psychiatry — Iowa City, Iowa, United States
• Children's Hospital of Philadelphia with the University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• University of Texas Health Science Center at Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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