Retrospective Review of Esophageal Cancer at MSKCC

Recruiting now

Conditions studied: Esophageal Cancer, Esophagus Cancer

In brief

Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, the investigators sought to evaluate the prognostic significance of the CRM in patients with esophageal cancer undergoing resection.

Key facts

Study ID

NCT05706558

Run by

Memorial Sloan Kettering Cancer Center

People needed

4000

Starts

2016-12-13

Expected to finish

2027-02-01

Last updated by the study team

2026-03-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy
• Pathologic staged T3 tumors (pT3)

You may not qualify if…

• Pathologic staged T0-2 (pT0-2) or T4 tumors (pT4)
• Patients with histologic types other than EAC or ESCC, dysplasia or carcinoma in situ without tumor invasion,
• Patients undergoing salvage esophagectomy
• Evidence of distant metastatic disease
• Patients with a positive proximal or distal margin

Where it is running

• Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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