Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Tourette Syndrome

In brief

This pilot study will investigate the clinical and neurophysiological effects of repetitive transcranial magnetic stimulation (rTMS) followed by comprehensive behavioral intervention for tics (CBIT) in adult patients with Tourette's Syndrome (TS). Two groups of moderate disease severity will be randomized to receive active or sham rTMS targeted to the supplementary motor area (SMA) followed by eight CBIT sessions. The change in tic frequency and severity (primary outcome) and neurophysiological changes (secondary outcome) will be compared between the two groups. The central hypothesis is that low frequency rTMS will augment the effects of CBIT through favorable priming of the SMA network.

Key facts

Study ID

NCT05705999

Run by

West Virginia University

People needed

20

Starts

2024-03-12

Expected to finish

2026-12-30

Last updated by the study team

2025-07-18

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older
• Diagnosis of Tourette Syndrome
• Moderate Tic Severity at baseline

You may not qualify if…

• Presence of metallic objects or neurostimulators in the brain
• Pregnancy
• History of active seizures or epilepsy
• Contraindications to receiving fMRI
• Inability to participate in CBIT due to other underlying cognitive or medical condition

Where it is running

• WVU RNI — Morgantown, West Virginia, United States (enrolling)

Full record on ClinicalTrials.gov

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