Study of Narazaciclib (ON 123300) Plus Letrozole in Endometrial Cancer and Other Gynecologic Malignancies

Status unconfirmed · Phase 1/Phase 2

Conditions studied: Endometrioid Endometrial Cancer

In brief

This study will assess the safety and efficacy of increasing doses of narazaciclib (ON 123300) in combination with the standard daily dose (2.5mg) of letrozole in patients with Recurrent Metastatic Low-grade Endometrioid Endometrial Cancer and other Gynecologic Malignancies.

Key facts

Study ID

NCT05705505

Run by

Traws Pharma, Inc.

People needed

60

Starts

2023-03-29

Expected to finish

2026-02-01

Last updated by the study team

2023-12-12

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Must be 18 years of age, or the legal age of consent in the jurisdiction in which the study is taking place, at the time of signing informed consent form (ICF).
• Phase 1 (Dose escalation cohorts): Have confirmed endometrial or other gynecologic malignancy that is amenable for treatment with hormonal therapy and do not have other standard treatment options. (Patients with endometrioid and other types of uterine cancer as well as ovarian cancers may be enrolled at the Investigator's discretion if hormonal based therapy is considered an appropriate option for the patient).
• OR Phase 2a (Dose expansion cohort): Have confirmed low-grade (Federation of Gynaecology and Obstetrics [FIGO] Grade 1 or 2) endometrioid endometrial cancer (LGEEC). Mixed tumor histology is allowed if the non-endometrioid component is <5%.
• Recurrent metastatic disease or advanced (Stage IV) disease.
• Phase 1 (Dose escalation cohorts): Patients may be enrolled regardless of prior checkpoint inhibitor therapy, at the Investigator's discretion.
• OR Phase 2a (Dose expansion cohort): Have received prior checkpoint inhibitor therapy (single agent or in combination with another anti-cancer therapy) if available for this indication and NOT contraindicated.
• Phase 1 (Dose escalation cohorts): Patients may be enrolled who have not received prior therapy for recurrent/metastatic disease, or have received any number of prior lines of therapy for recurrent/metastatic disease, at the Investigator's discretion.
• OR Phase 2a (Dose expansion cohort): Have received 1 or 2 prior lines of systemic therapy for metastatic disease. Patient has NOT received more than 2 prior lines of systemic therapy for metastatic LGEEC (including checkpoint inhibitor, hormone therapy, or chemotherapy). Prior external beam radiotherapy, brachytherapy, and/or surgery for localized disease is allowed and is not counted as a line of therapy.
• Phase 1 (Dose escalation cohorts): Have either measurable or non- measurable disease.
• OR Phase 2a (Dose expansion cohort): Have measurable disease outside the radiated field.
• Local mismatch repair (MMR) immunohistochemistry (IHC) results available (both deficient mismatch repair (dMMR) and mismatch repair protein (MMRP) deficiency (MMRp) patients are eligible, and will be documented for research purposes).
• Have Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1.
• Tissue for estrogen/progesterone receptor status and molecular classification (paraffin embedded or fresh biopsy if unavailable).
• Have adequate organ function as indicated by the following:
• Absolute neutrophil count (ANC) ≥1.0×109/L
• Platelets ≥100×109/L
• Hemoglobin ≥9.0 g/dL
• International Normalized Ratio (INR) ≤1.5
• Serum creatinine ≤1.5 times ULN, or estimated creatinine clearance (calculated according to normal institutional practice) greater than 50 milliliters (ml)/min
• Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) below 3.0×the upper limit of normal (ULN) (or ALT and AST ≤5×ULN if liver metastases are present).
• Total serum bilirubin <1.5×ULN; or total bilirubin ≤3.0×ULN with direct bilirubin within normal range of the central laboratory in participants with well documented Gilbert's Syndrome.
• Have baseline corrected QT (QTc) interval <470 msec.
• Are able to swallow oral medications.
• Have a life expectancy of at least 12 weeks
• Sex and Contraceptive/Barrier Requirements

You may not qualify if…

• Phase 1 (Dose escalation cohorts): Cancer other than endometrial or other gynecologic malignancy.
• OR Phase 2a (Dose expansion cohort): Non-low-grade EEC (not FIGO Grades 1 or 2) or non-endometrioid adenocarcinoma, sarcoma, small cell carcinoma with neuroendocrine differentiation, or non-epithelial cancers as exclusion criteria.
• Have received a cyclin-dependent kinase (CDK) 4/6 inhibitor in the past.
• Have any significant medical condition, laboratory abnormality, or psychiatric illness that, in the opinion of the Investigator, would prevent the patient from participating in the study or present an unacceptable risk to the patient.
• Are at risk for Torsades de pointes (TdP): Patients who have a marked baseline prolongation of QT/QTc interval (eg, repeated demonstration of a QTc interval >470 msec) using Fredericia's QT correction formula, or who have a history of additional risk factors for TdP (eg, heart failure, hypokalemia, family history of Long QT Syndrome), or who are currently taking medications that prolong the QT/QTc interval.
• Have uncontrolled intercurrent or significant medical illness, serious underlying medical condition, abnormal laboratory finding, or psychiatric illness/social situation that might, in the Investigator's or the Sponsor's judgment, prevent the participant from receiving study treatment or being followed in this study, or otherwise renders the participant inappropriate for the study, including but not limited to ongoing or active infection, bleeding, congestive heart failure, unstable angina, cardiac arrhythmia, oxygen-dependent lung disease, and psychiatric illness/social situations that limit participation compliance with study procedures and requirements.
• Are currently taking or within 5 half-lives of taking strong inducers and inhibitors of cytochrome P450 enzyme (CYP)2C8 and CYP3A4.
• Have a recent history of venous thromboembolic events, defined as event occurring <6 months prior to screening and also currently on therapy, known underlying hypercoagulability, or a major thromboembolic event within the past 2 years.
• Have baseline Grade ≥2 diarrhea.
• Have Grade ≥3 hypercalcemia (corrected serum calcium >12.5 mg/dL).
• Are pregnant or nursing mothers.
• Have had major surgery within 14 days prior to screening to allow for postoperative healing of the surgical wound and site(s).
• Have received recent (within 28 days prior to screening) live attenuated vaccines.
• Have active infection, including bacterial or fungal infections or active viral infection or viral load, including any human immunodeficiency virus (HIV), or hepatitis B virus (HBV), hepatitis C virus (HCV), or Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (COVID-19).
• Currently have or have been treated in the past 2 years, for any other cancer or malignancy, except:
• Non-melanoma skin cancer, including basal cell carcinoma of the skin
• Curatively treated carcinoma in situ of the cervix.
• Have any clinically significant, uncontrolled heart disease, and/or cardiac repolarization abnormality, or a history of any of the following:
• Syncope of cardiovascular etiology
• Ventricular arrhythmia of pathological origin
• Sudden cardiac arrest
• Documented history of congestive heart failure with reduced ejection fraction.
• Have interstitial pneumonia or has severe impairment of lung function defined as:
• Vital capacity and diffusing capacity of the lung for carbon monoxide (DLCO) of ≤50% of the normal predicted values, or
• Oxygen (O2) saturation at rest in ambient environment of ≤88%.

Where it is running

• Arizona Oncology Associates, PC - HOPE — Tucson, Arizona, United States (enrolling)
• Minnesota Oncology Hematology, P.A. — Minneapolis, Minnesota, United States (enrolling)
• Perlmutter Cancer Center at NYU Langone Hospital - Long Island — Mineola, New York, United States (enrolling)
• NYU Langone — New York, New York, United States (enrolling)
• Willamette Valley Cancer Institute and Research Center — Eugene, Oregon, United States (enrolling)
• Greenville Health System, Institute for Oncology Clinical Research — Greenville, South Carolina, United States (enrolling)
• Texas Oncology-Baylor Charles A. Sammons Cancer Center — Dallas, Texas, United States (enrolling)
• Texas Oncology - Fort Worth Cancer Center — Fort Worth, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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