The Diabetes Prevention Program Outcomes Study AD/ADRD Project
Enrolling by invitation
Conditions studied: Diabetes, Alzheimer Disease, Dementia, Vascular, Dementia, PreDiabetes
In brief
The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for cognitive impairment and represent a large fraction of the United States (US) population? This U19 proposal addresses the National Alzheimer's Project Act goal to "prevent, halt, or reverse AD" in the high-risk group of persons with pre-diabetes and type 2 diabetes, who represent over half of the population aged 60 years and older in the US.
Key facts
- Study ID
- NCT05704309
- Run by
- Marinella Temprosa
- People needed
- 1976
- Starts
- 2022-11-07
- Expected to finish
- 2027-08-30
- Last updated by the study team
- 2025-08-26
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- All surviving participants originally randomized in the Diabetes Prevention Program
- For Brain Imaging subcohort, only participants aged 55 years and older and those without contraindication to MRI will be included. Contraindications to MRI include the inability to lie flat, claustrophobia, and the presence of indwelling metallic objects, medical or non-medical, that are not 3T MRI compatible.
Where it is running
- SW American Indian Center - Phoenix — Phoenix, Arizona, United States
- University of California Los Angeles — Alhambra, California, United States
- University of California San Diego — San Diego, California, United States
- University of Colorado — Aurora, Colorado, United States
- Medstar Health Research Institute — Washington D.C., District of Columbia, United States
- University of Miami — Miami, Florida, United States
- University of Hawaii — Honolulu, Hawaii, United States
- Northwestern University — Chicago, Illinois, United States
- University of Chicago — Chicago, Illinois, United States
- Indiana University — Indianapolis, Indiana, United States
- Pennington Biomedical Center — Baton Rouge, Louisiana, United States
- Johns Hopkins University — Lutherville, Maryland, United States
- Biostatistics Center, George Washington University — Rockville, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Joslin Diabetes Center — Boston, Massachusetts, United States
- Washington University — St Louis, Missouri, United States
- University of New Mexico — Albuquerque, New Mexico, United States
- SW American Indian Center - Shiprock — Shiprock, New Mexico, United States
- SW American Indian Center - Zuni — Zuni, New Mexico, United States
- Columbia University Medical Center — New York, New York, United States
- Columbia University — New York, New York, United States
- Albert Einstein College of Medicine — The Bronx, New York, United States
- Thomas Jefferson University — Philadelphia, Pennsylvania, United States
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
- University of Tennessee — Memphis, Tennessee, United States
Full record on ClinicalTrials.gov
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