Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease

Recruiting now · Phase 4

Conditions studied: COPD Exacerbation, COPD Exacerbation Acute

In brief

The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The primary objective is to determine whether a titrated oxygen strategy targeting SpO₂ 88-92% can reduce 30-day mortality compared to the current standard practice using 100% compressed oxygen as a nebulizer driver.

Key facts

Study ID

NCT05703919

Run by

Central Denmark Region

People needed

1888

Starts

2025-06-02

Expected to finish

2028-05-31

Last updated by the study team

2025-06-10

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients over the age of 40
• EMT or Paramedic suspected AECOPD
• Confirmed suspicion of COPD

You may not qualify if…

• Bronchospasm due to asthma, allergic reaction or non-COPD conditions
• Known or suspected pregnancy
• Prehospital Non-invasive, invasive or assisted bag mask ventilation
• Allergy to inhaled bronchodilators (Salbutamol)
• Inter-hospital transfer
• More than 2 doses (5 mg salbutamol) inhalation drug, acute treatment by EMS (emergency medical service) personnel, before allocated treatment is initiated
• Suspicion of acute coronary syndrome

Where it is running

• Prehospital Emergency Medical Servises, Central Denmark Region — Aarhus N, Denmark (enrolling)

Full record on ClinicalTrials.gov

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