Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain

Recruiting now

Conditions studied: Chronic Pain

In brief

The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.

Key facts

Study ID

NCT05701852

Run by

Fondation Ophtalmologique Adolphe de Rothschild

People needed

50

Starts

2023-12-19

Expected to finish

2027-05-01

Last updated by the study team

2026-01-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin.
• For controls: matched to a case on age (±5 years) and sex

You may not qualify if…

• Neurodegenerative or inflammatory neurological pathology
• Clinical depressive syndrome
• High doses of opioid treatment (greater than 100 mg/day of morphine equivalent)
• Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks
• Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)

Where it is running

• Hôpital Fondation Adolphe de Rothschild — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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