Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress

Recruiting now · Not applicable

Conditions studied: Post Traumatic Stress Disorder, Complex Posttraumatic Stress Disorder, Stress, Burn Out, Mental Health Issue

In brief

In the last four years alone, residents of Puerto Rico have experienced a slew of natural disasters including Hurricane Maria in 2017, earthquakes in 2019 and 2020, the continued COVID-19 pandemic from 2020-2022, and most recently Hurricane Fiona. This series of distressing events can lead to an increased need for mental health resources and trauma treatment. Furthermore, the unique single-district structure of the Puerto Rican education system allows for the efficient dissemination of potential interventions and treatment to all students. The purpose of this study is to examine two treatment conditions for educators and school-aged children in Puerto Rico experiencing burnout, fatigue, and high stress: delivery of a mindfulness-based educator curriculum and, for children who report Post Traumatic Stress Disorder (PTSD) symptomatology, delivery of the mindfulness curriculum with the additional intervention of Cue-Centered Therapy (CCT). The study has two aims: 1) To assess the efficacy of the mindfulness curriculum and of CCT in a population of students, counselors, and teachers, characterized by high stress over the last few years of natural disasters and pandemic challenges and 2) To identify genetic contributions to resilience by analyzing gene expression in students before and after the intervention. The overarching goals of the investigators' research collaboration are to improve educators' psychological well-being and children's socioemotional development when faced with high stress and adversity and to improve mental health clinicians' competence and confidence in treating children exposed to trauma by training them in CCT. The investigators' research will identify critical biopsychosocial components responsible for the cognitive, behavioral, and emotional improvement and effective implementation strategies in a large but geographically dispersed school district. The knowledge base that will result from this study will inform the implementation of trauma-informed care in school settings and with populations experiencing stress and adversity, and contribute to the investigators' understanding of the underlying biology of these interventions to provide a rationale for further development and dissemination.

Key facts

Study ID: NCT05701111
Run by: Stanford University
People needed: 80800
Starts: 2024-02-23
Expected to finish: 2027-05-01
Last updated by the study team: 2025-07-18

Who can join

Age: 11 and older, up to 17. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Teachers and students at a participating school site, Adults and students/caregivers willing to participate in the study
For Cue Centered Therapy:
Youth aged 11-17 with exposure to at least one Diagnostic Statistical Manual (DSM) 5-defined traumatic event and meeting threshold criteria for posttraumatic symptoms per the University of California Los Angeles (UCLA) PTSD scale.
Willingness to participate in therapy
Caregiver willing to participate in therapy
Perpetrator of the traumatic event is not living in the home with the child

You may not qualify if…

For the general study and for Cue Centered Therapy:
Students doing current trauma-focused interventions with a mental health professional
Low cognitive functioning (IQ less than 70)
Substance dependence as defined by DSM criteria
Autism/Schizophrenia
Clinically significant medical illness

Where it is running

Department of Education Puerto Rico — San Juan, Puerto Rico (enrolling)
Stanford University — Palo Alto, California, United States
Centros Sor Isolina Ferre — San Juan, Puerto Rico, Puerto Rico

Full record on ClinicalTrials.gov

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