Integrated Molecular and Clinical Profiling to Improve Disease Characterization and Outcome Prediction in Nodal Marginal Zone Lymphoma

Recruiting now

Conditions studied: Nodal Marginal Zone Lymphoma

In brief

International retrospective observational cohort study aimed to describe a molecular classification for NMZL.

Key facts

Study ID

NCT05700149

Run by

International Extranodal Lymphoma Study Group (IELSG)

People needed

300

Starts

2024-04-11

Expected to finish

2026-12-31

Last updated by the study team

2026-06-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female adults 18 years or older
• Diagnosis of NMZL on lymph node histology after Jan 1st, 2000
• Availability of tumor material from lymph node (either frozen or FFPE) collected when the patient was treatment naïve
• Availability of the baseline and follow-up annotations

You may not qualify if…

• Nodal spread of a clinically occult extranodal MZL (this must have been ruled out by carefully evaluating the extranodal tissues draining to the involved lymph nodes by imaging or endoscopy)

Where it is running

• University of Miami — Miami, Florida, United States (enrolling)
• Mayo Clinic — Rochester, Minnesota, United States (enrolling)
• Weill Cornell Medical — New York, New York, United States (enrolling)
• Ohio Health Riverside Methodist Hospital — Columbus, Ohio, United States (enrolling)
• Hospital Italiano de Buenos Aires — Buenos Aires, Argentina (enrolling)
• Hematology Center after Prof. Yeolyan — Yerevan, Armenia (enrolling)
• Princess Margaret Cancer Centre — Toronto, Canada (enrolling)
• University Hospital Centre Zagreb — Zagreb, Croatia (enrolling)
• CHU Grenoble Alpes — Grenoble, France (enrolling)
• Institut Universitaire du Cancer de Toulouse — Toulouse, France (enrolling)
• Tata Memorial Hospital — Mumbai, India (enrolling)
• AO SS Antonio e Biagio e C. Arrigo — Alessandria, AL, Italy (enrolling)
• Istituto Tumori "Giovanni Paolo II" I.R.C.C.S. — Bari, BA, Italy (enrolling)
• ASST Papa Giovanni XXIII — Bergamo, BG, Italy (enrolling)
• ASST degli Spedali Civili di Brescia — Brescia, BS, Italy (enrolling)
• AOU Policlinico Vittorio Emanuele, Presidio Ferrarotto — Catania, CT, Italy (enrolling)
• Azienda Ospedaliero Universitaria di Ferrara — Cona, FE, Italy (enrolling)
• Azienda Ospedaliera Universitaria Careggi — Florence, FI, Italy (enrolling)
• Azienda Ospedaliera Papardo — Messina, ME, Italy (enrolling)
• IRCCS Ospedale San Raffaele — Milan, MI, Italy (enrolling)
• IEO Istituto Europeo di Oncologia — Milan, MI, Italy (enrolling)
• ASST Grande Ospedale Metropolitano Niguarda — Milan, MI, Italy (enrolling)
• Azienda Sanitaria Locale di Pescara — Pescara, PE, Italy (enrolling)
• Centro di Riferimento Oncologico — Aviano, PN, Italy (enrolling)
• Fondazione IRCCS Policlinico San Matteo — Pavia, PV, Italy (enrolling)

Full record on ClinicalTrials.gov

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