Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
Completed
Conditions studied: Parkinson's Disease, Multiple System Atrophy, Parkinson Variant, Multiple System Atrophy
In brief
The objective of this study is to describe disease progression in study participants diagnosed with early Parkinson's Disease or Multiple System Atrophy - Parkinsonian Type up to 18 months as delineated by clinical and biochemical parameters.
Key facts
- Study ID
- NCT05699460
- Run by
- AskBio Inc
- People needed
- 73
- Starts
- 2022-09-29
- Expected to finish
- 2025-11-04
- Last updated by the study team
- 2026-07-27
Who can join
Age: 35 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of Idiopathic PD
- Diagnosis of MSA-P
- One to six years from clinical diagnosis of PD
- Less than 4 years from clinical diagnosis of MSA with expected survival >3 years
- Stable medication regimen
- Ability to walk with or without an assistive device
You may not qualify if…
- Movement disorder due to known cerebrovascular disease, brain tumor, trauma, exposure to parkinsonian-linked toxicants or other neurological diseases
- Presence of dementia, psychosis, substance abuse or poorly controlled depression
- Prior brain surgery (i.e. deep brain stimulation) or other brain imaging abnormalities
- History of cancer or poorly controlled medical conditions
- Receiving an investigational drug
- NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Where it is running
- University of California Irvine — Irvine, California, United States
- Parkinson's Disease and Movement Disorders Center of Boca Raton — Boca Raton, Florida, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Quest Research Institute — Farmington Hills, Michigan, United States
- Ohio Health Research Institute — Columbus, Ohio, United States
- OHSU Parkinson Center & Movement Disorders Program — Portland, Oregon, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
- Zespol Poradni Specjalistycznych - Botaniczna 3 Poradnia Neurologiczna Szpital Uniwersytecki w Krakowie — Krakow, Lesser Poland Voivodeship, Poland
- Specjalistyczna Praktyka Lekarska, Prof. Grzegorz Opala — Katowice, Poland
- Mazowiecki Szpital Bródnowski w Warszawie, Oddział Neurologii — Warsaw, Poland
- Samodzielny Publiczny Szpital Kliniczny im. prof. Witolda Orłowskiego, Oddział Neurologii i Epileptologii — Warsaw, Poland
Full record on ClinicalTrials.gov
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