Low Dose Antenatal Corticosteroids for Late Preterm Delivery
Recruiting now · Not applicable
Conditions studied: Respiratory Morbidity, Preterm Labor
In brief
This is a study proposal for a clinical trial to evaluate the effectiveness of a reduced dose of antenatal betamethasone (a steroid medication) in preventing respiratory problems in late preterm infants (born between 34 and 36 weeks of gestation). The study will be conducted in medical centers in Israel and will involve women who are at high risk for delivering a late preterm infant. The participants will be randomly assigned to receive either a full dose (12 mg) or a quarter dose (3 mg) of betamethasone, administered 24 hours apart. The main outcome measure of the study will be the incidence of respiratory problems or neonatal death within 72 hours of delivery in the two groups. The study is designed to determine if the reduced dose of betamethasone is non-inferior (i.e., not significantly worse) than the full dose in preventing respiratory problems in late preterm infants.
Key facts
- Study ID
- NCT05698966
- Run by
- Rambam Health Care Campus
- People needed
- 1510
- Starts
- 2022-01-01
- Expected to finish
- 2028-01-01
- Last updated by the study team
- 2024-04-10
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Emek Medical Center — Afula, Israel (enrolling)
- Kaplan Medical Center — Ashkelon, Israel (enrolling)
- Soroka Medical Center — Beersheba, Israel (enrolling)
- Hilel Yafee Medical Center — Hadera, Israel (enrolling)
- Bnai Zion Medical Center — Haifa, Israel (enrolling)
- Carmel Medical Center — Haifa, Israel (enrolling)
- Rambam Health Care Cmpus — Haifa, Israel (enrolling)
- Hadassah Ein Karem — Jerusalem, Israel (enrolling)
- Hadassah Har Hzofim — Jerusalem, Israel (enrolling)
- Shaare Zedek Medical Center — Jerusalem, Israel (enrolling)
- Meir medical center — Kfar Saba, Israel (enrolling)
- Galilee Medical Center — Nahariya, Israel (enrolling)
- Rabin Medical Center — Petah Tikva, Israel (enrolling)
- Sheba Medical Center — Ramat Gan, Israel (enrolling)
- Ziv Medical Center — Safed, Israel (enrolling)
- Sourasky Medical Center — Tel Aviv, Israel (enrolling)
Full record on ClinicalTrials.gov
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