HP Pyruvate MRI in Cancers

Recruiting now · Phase 1/Phase 2

Conditions studied: Image, Warburg Effect, Tumors

In brief

Many human diseases are characterized by their ability to alter existing metabolic pathways and interrupt cellular processes. Cancer exploits the Warburg effect and utilizes greater glucose than normal cells and within this process uses anaerobic respiration, leading to increased conversion of pyruvate to lactate. This can be exploited by hyperpolarized imaging. Hyperpolarized 13C MRI imaging is an approach that utilizes a stable isotope of Carbon (13C) linked to pyruvate. MRI spectroscopy is used in conjunction with hyperpolarized 13C pyruvate in order to temporally detect pyruvate and its conversion to lactate in-vivo, in order to visualize downstream metabolic (glycolytic) activity secondary to the Warburg effect, which should be useful in detecting and characterizing tumors of various types. Hyperpolarized 13C pyruvate MR imaging has not been tested in most cancers. In this preliminary survey, we will test the hypothesis that hyperpolarized 13C pyruvate MR imaging can be used to image various cancers.

Key facts

Study ID

NCT05697406

Run by

University of Maryland, Baltimore

People needed

25

Starts

2024-06-24

Expected to finish

2028-12-01

Last updated by the study team

2025-09-22

Who can join

Age: 18 and older, up to 88. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical tumor diagnosis
• Patients with pre-existing MR imaging appointments
• Must be able to undergo MR

You may not qualify if…

• No tumor diagnosis

Where it is running

• University of Maryland Medical Center — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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