PRospective REgistry of Advanced Stage CancER (PREFER) Patients to Assess Prevalence of Actionable Biomarkers and Driver Mutations to Address Disparities in Precision Medicine

Completed

Conditions studied: Lung Cancer, Ovarian Cancer, Uterine Cancer, Colorectal Cancer, Stomach Cancer, Esophageal Cancer, Pancreatic Cancer, Melanoma, Breast Cancer, Head and Neck Cancer, Soft Tissue Sarcoma, Rhabdomyosarcoma, Prostate Cancer

In brief

The objective of this Study is to collect, process, and transfer biologic samples such as blood and/or tissue biopsies to determine the concordance of detected alterations obtained through liquid biopsy analyses compared to next generation sequencing of time-matched or archival tissue specimens from individuals with advanced solid tumors. Examples of locally advanced and metastatic tumors include stage III and IV cancers (ex. lung, breast, all gastrointestinal malignancies, all gynecologic malignancies, prostate cancer, head and neck tumors, soft tissue cancers, and melanoma). These specimens will be analyzed for diagnostic purposes and research (either by Labcorp/OmniSeq or to a third-party recipient designated by Labcorp/OmniSeq). Labcorp/OmniSeq may transfer the specimens and data to its clients, including commercial, academic or non-profit research institutions; or alternatively, may retain the specimens in its repository for future research use at the sole discretion of Labcorp/OmniSeq and or assignees. Labcorp/OmniSeq will maintain all detailed clinical information including demographic data (de-identified), ethnicity, disease state, stage (radiological, pathological and clinical-whichever is relevant).

Key facts

Study ID

NCT05697198

Run by

Labcorp Corporation of America Holdings, Inc

People needed

1429

Starts

2021-04-19

Expected to finish

2024-12-31

Last updated by the study team

2025-03-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Subjects incapable of understanding the items listed in the ICF and the consent process
• Pregnant females
• Subjects with a history of or known psychiatric illness that deems them unable to consent

Where it is running

• Clinical Site — Fort Payne, Alabama, United States
• Clinical Site — Orange City, Florida, United States
• Clinical Site — Stuart, Florida, United States
• Clinical Site — Dublin, Georgia, United States
• Clinical Site — Fort Wayne, Indiana, United States
• Clinical Site — Covington, Louisiana, United States
• Clinical Site — Huntersville, North Carolina, United States
• Clinical Site — Rock Hill, South Carolina, United States

Full record on ClinicalTrials.gov

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