7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis

Recruiting now

Conditions studied: Rheumatoid Arthritis, Sickness Behavior, Inflammatory Disease, Autoimmune, Pain, Chronic

In brief

This is an experimental medicine, single-centre, observational test-retest study to evaluate Filgotinib's mechanism of analgesic action in RA patients. The investigators hypothesize that Filgotinib's mechanism of analgesic action is determined by at least two factors. The first is related to those CNS sensitization pathways seen in fibromyalgia, specifically DMN-insula brain functional connectivity and insular glutamate. The second is related to peripheral inflammation, specifically joint synovitis, blood cytokines/chemokines and DAN-LIPL functional brain connectivity. The CNS sensitization pain pathways related to fibromyalgia are more quickly modified compared to those related to peripheral inflammation and help explain Filgotinib's rapid onset of effect.

Key facts

Study ID

NCT05697159

Run by

NHS Greater Glasgow and Clyde

People needed

20

Starts

2023-08-22

Expected to finish

2025-10-31

Last updated by the study team

2025-01-14

Who can join

Age: 18 and older, up to 74. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with moderate to severe active RA who have been prescribed filgotinib in line with the Summary of Product Characterisation and are:
• Adults ≥18 years < 75 years.
• Right-handed (to reduce neuroimaging heterogeneity).

You may not qualify if…

• Inability to provide written informed consent.
• Severe physical impairment (e.g. blindness, deafness, paraplegia).
• Pregnant or breast feeding.
• Severe claustrophobia precluding MRI.
• Contraindications to MRI.
• Major confounding neurological disease including MS, Stroke, Traumatic Brain Injury.
• Previous targeted synthetic (e.g. baricitinib, tofacitinib) DMARD exposure for RA.

Where it is running

• Neil Basu — Glasgow, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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