Feasibility of Resistance Exercise to Treat Major Depression Via Cerebrovascular Mechanisms

Completed · Not applicable

Conditions studied: Major Depressive Disorder

In brief

This project is a single-arm pilot trial to investigate the feasibility, acceptability, and plausible efficacy of a 16-week resistance exercise training (RET) program for treatment of major depressive disorder.

Key facts

Study ID

NCT05695365

Run by

Iowa State University

People needed

9

Starts

2022-04-04

Expected to finish

2023-01-10

Last updated by the study team

2024-03-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Be diagnosed with DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) MDD confirmed via Structured Clinical Interview for DSM-5
• Have current depressive symptoms of at least mild severity defined by a Hamilton Rating Scale of Depression score greater than or equal to 8
• Be ages 18-65
• Have not changed psychological treatments (including drugs, behavioral and psychological treatments) in the past 8 weeks and willing to maintain treatments throughout study enrollment
• Safe to exercise based on Physical Activity Readiness Questionnaire (PARQ) responses

You may not qualify if…

• Currently pregnant, nursing, or planning to become pregnant during the study
• Currently diagnosed with a drug or alcohol use disorder (via SCID)
• Comorbid psychiatric conditions confirmed via SCID, with the exception of Generalized Anxiety Disorder (GAD; due to high comorbidity)
• Class II or greater level of obesity (BMI greater than or equal to 35)
• High active suicidal ideation with specific plan and intent ('4' or '5' score on Suicidal Ideation from Columbia Suicide Severity Rating Scale or '3' on QIDS)
• Currently meets US resistance exercise recommendations per week (2 days per week) for the last 8 weeks
• Self-reported prior cardiovascular event or condition, stroke or pulmonary, renal, or neurological disease
• Self-reported diabetes mellitus
• Self-reported recent (within 3 months) severe concussion, in which the individual lost consciousness for any amount of time
• Self-reported smoking/vaping

Where it is running

• Iowa State University — Ames, Iowa, United States

Full record on ClinicalTrials.gov

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