Novel Treatment for Dental Ankylosis

Completed · Not applicable

Conditions studied: Dental Ankylosis

In brief

The study is to determine whether one (or two) new method(s) will help treat dental ankylosis. This study tackles the challenging tooth-bone fusion disorder of ankylosis. In growing patients, ankylosis causes significant developmental bone defects due to its inhibition of the vertical growth of the affected alveolar bone area.

Key facts

Study ID

NCT05695105

Run by

Rutgers, The State University of New Jersey

People needed

5

Starts

2023-07-10

Expected to finish

2025-12-16

Last updated by the study team

2026-01-15

Who can join

Age: 6 and older, up to 30. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Full informed consent and/or informed assent (minors)
• Be willing and able to comply with all study requirements
• Male or female
• Aged 6-30
• Clinically diagnosed to have either an ankylosed deciduous tooth or a non-third molar mildly- to moderately- ankylosed permanent tooth, and with crown partially visible in the oral cavity. Clinical diagnosis of ankylosis includes the following factors: dental trauma history, infra-eruption with no apparent mechanical obstruction or other cause, contralateral tooth in occlusal contact for over one year, decreased alveolar bone height, no or reduced tooth mobility, and x-ray or cone-beam computer tomography (CBCT) imaging indications of an obliterated PDL space. Ultimately, the diagnosis will be confirmed by lack of tooth movement discovered during orthodontic treatment or when subjected to a heavy force through our study (Phelan M K, et al. 1990).
• English speaking (primary language or fluent)

You may not qualify if…

• Severe and extensive ankylosis of permanent teeth as diagnosed through CBCT
• Primary failure of eruption with previous orthodontic treatment
• Any systemic disorders particularly those affecting bleeding or skeletal health
• Any systemic medications
• Any mental or developmental disorders that affect patient understanding or compliance
• Allergic to our local anesthetic drug
• Can pass an infectious disease to someone else right now (e.g., having a flu)
• Is pregnant
• Has a history of smoking
• Have not reached the age of 6 or older than age of 30
• Not cooperative enough during dental examinations
• The dentist finds out that he/she is not able to keep the mini-implant, the brackets and the wires in place around the tooth that is being treated
• Not fluent in English

Where it is running

• Rutgers School of Dental Medicine — Newark, New Jersey, United States

Full record on ClinicalTrials.gov

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