Evaluation of Volume and Electrolyte Balance in Hyponatremia Treatment - a Prospective Observational Trial

Recruiting now

Conditions studied: Non-hypervolemic Hyponatremia

In brief

To assess quantitatively the evolution over time of electrolyte-free water clearance and electrolyte mass balance in patients with non-hypervolemic hypotonic hyponatremia

Key facts

Study ID

NCT05692726

Run by

University of Cologne

People needed

50

Starts

2022-10-15

Expected to finish

2026-09-30

Last updated by the study team

2025-09-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients ≥ 18 years
• Hypotonic hyponatremia
• glucose-corrected plasma sodium <130 mmol/l
• serum osmolality <280 mosmol/kg or lack of signs of non-hypotonic hyponatremia

You may not qualify if…

• Signs of extracellular volume expansion
• Patients with liver cirrhosis and severe liver damage AST/ALT>3xULN, AP>6xULN, Bilirubin ≥ 3mg/dl
• Patients with heart failure
• Patients on dialysis and/or patients with oliguric renal impairment and plasma creatinine ≥ 3mg/dl
• Patients after organ transplantation

Where it is running

• University Hospital of Cologne — Cologne, Germany (enrolling)

Full record on ClinicalTrials.gov

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