Barrett's Esophagus and Esophageal Adenocarcinoma, Searching for Reliable Diagnostic RNA Plasma-based Biomarkers

Recruiting now

Conditions studied: Esophageal Neoplasms

In brief

This study is designed to perform a explorative search of the transcriptome to detect new circulating diagnostic sensitive and specific biomarkers in patients with Barrett's esophagus or esophageal adenocarcinoma.

Key facts

Study ID

NCT05688176

Run by

University Hospital, Ghent

People needed

100

Starts

2016-06-01

Expected to finish

2027-01-31

Last updated by the study team

2024-07-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Barrett's Esophagus with length > 3cm OR esophageal adenocarcinoma histologically proven
• Adequate mental faculty, allowing to understand the proposed treatment protocol and provide informed consent
• Age over 18 years
• No other concurrent malignant disease
• No inclusion in other clinical trials interfering with the study protocol
• No concurrent chronic systemic immune or hormone therapy, except neoadjuvant chemotherapy
• Absence of any severe organ insufficiency
• No pregnancy or breast feeding
• Written informed consent

You may not qualify if…

• Pregnancy or breast feeding
• Active bacterial, viral or fungal infection
• Parenchymal liver disease (any stage cirrhosis)
• High risk of bleeding during biopsy (anticoagulants, esophageal varices)
• Esophageal squamous cell carcinoma
• Helicobacter pylori positive at the time of biopsy sampling
• Radiofrequency ablation of the oesophagus
• Psychiatric pathology capable of affecting comprehension and judgement faculty

Where it is running

• University hospital Ghent — Ghent, Oost-Vlaanderen, Belgium (enrolling)

Full record on ClinicalTrials.gov

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