Adverse Events Related to Low Dose Atropine

Completed

Conditions studied: Myopia, Progressive

In brief

Progressive myopia can lead to severe vision loss and is associated with retinal detachment, glaucoma, and other comorbidities. Several studies have shown that off-label, low-dose atropine eye drops slow the progression of myopia. Many eye care providers are now prescribing off-label atropine eye drops for their myopic patients, with the prescribed concentrations varying amongst providers. The purpose of this study is to determine if low-dose atropine eyedrops used daily, cause adverse effects to the eyes. Patients currently using 0.01%, 0.03%, or 0.05% atropine eye drops obtained from compounding pharmacies will be assessed for associated adverse effects.

Key facts

Study ID

NCT05683535

Run by

Scripps Health

People needed

148

Starts

2018-06-19

Expected to finish

2023-01-09

Last updated by the study team

2023-04-25

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• patients diagnosed with myopia
• patients must be currently using 0.01%, 0.03%, or 0.05% atropine eye drops daily
• low-dose atropine eye drops must be prescribed by the principal investigator and obtained from a compounding pharmacy

You may not qualify if…

• patients without myopia
• patients with myopia, but not using low-dose atropine eye drops

Where it is running

• Laura Kirkeby — San Diego, California, United States

Full record on ClinicalTrials.gov

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