CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)

Running, not enrolling · Phase 3

Conditions studied: Severe Hypertriglyceridemia

In brief

The purpose of this study is to evaluate the safety and tolerability of olezarsen in participants with SHTG.

Key facts

Study ID

NCT05681351

Run by

Ionis Pharmaceuticals, Inc.

People needed

885

Starts

2022-12-13

Expected to finish

2027-03-01

Last updated by the study team

2025-12-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of Cape Town — Cape Town, South Africa
• Hospital Abente y Lago — A Coruña, Spain
• Hospital Germans Trias i Pujol — Badalona, Spain
• Medi Clinic Vergelegen — Cape Town, South Africa
• Medical Center Zara-Med — Stara Zagora, Bulgaria
• LA Universal Research Center, Inc. — Los Angeles, California, United States
• University of California, San Diego (UCSD) — San Diego, California, United States
• Metabolic Institute of America — Tarzana, California, United States
• Excel Medical Clinical Trials — Boca Raton, Florida, United States
• Finlay Medical Research — Greenacres City, Florida, United States
• Columbus Clinical Services, LLC — Miami, Florida, United States
• Finlay Medical Research — Miami, Florida, United States
• Innovia Research Center, Inc. — Miramar, Florida, United States
• Harmony Clinical Research, Inc. — North Miami Beach, Florida, United States
• R & B Medical Center LLC — Tampa, Florida, United States
• VICIS Clinical Research — Tampa, Florida, United States
• JSV Clinical Research Study, Inc. — Tampa, Florida, United States
• Bayside Clinical Research — Trinity, Florida, United States
• Centricity Research — Columbus, Georgia, United States
• IACT Health — Columbus, Georgia, United States
• Affinity Health — Oak Brook, Illinois, United States
• St. Vincent Medical Group, Inc. — Carmel, Indiana, United States
• University of Kansas Medical Center (KUMC) — Kansas City, Kansas, United States
• The Research Group of Lexington, LLC — Lexington, Kentucky, United States
• TREAD Research — Cape Town, South Africa

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.