Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1
Running, not enrolling · Phase 3
Conditions studied: Autosomal Dominant Hypocalcemia (ADH)
In brief
The primary purpose of the study is to understand the effectiveness, safety, and tolerability of encaleret when compared to standard of care (SoC) treatment in participants with Autosomal Dominant Hypocalcemia Type 1 (ADH1).
Key facts
- Study ID
- NCT05680818
- Run by
- Calcilytix Therapeutics, Inc., a BridgeBio company
- People needed
- 67
- Starts
- 2023-01-06
- Expected to finish
- 2029-08-01
- Last updated by the study team
- 2026-07-29
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UCSF Benioff Children's Hospital, Oakland — Oakland, California, United States
- Children's Hospital Colorado — Aurora, Colorado, United States
- Indiana University Health University Hospital — Indianapolis, Indiana, United States
- NIH — Bethesda, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Mayo Clinic - Rochester — Rochester, Minnesota, United States
- Columbia University Irving Medical Center — New York, New York, United States
- Physicians East — Greenville, North Carolina, United States
- Ohio State University Medical Center — Columbus, Ohio, United States
- The Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Houston Methodist Hospital — Houston, Texas, United States
- Royal North Shore Hospital — Saint Leonards, New South Wales, Australia
- Royal Brisbane and Women's Hospital — Herston, Queensland, Australia
- Bone Research & Education Centre — Oakville, Ontario, Canada
- Vseobecna fakultni nemocnice v Praze — New Town, Czechia
- Aarhus University Hospital — Aarhus, Denmark
- CHU Bicetre — Le Kremlin-Bicêtre, Le Kremlin-Bicêtre, France
- Hôpital Edouard Herriot - HCL — Lyon, France
- IRCCS Ospedale San Raffaele — Milan, Italy
- University Hospital of Pisa — Pisa, Italy
- Fondazione Policlinico Universitario Campus Bio-Medico — Roma, Italy
- The University of Tokyo Hospital — Tokyo, Japan
- Eramus MC — Rotterdam, Netherlands
- Freeman Hospital — Newcastle upon Tyne, United Kingdom
- Norfolk and Norwich University Hospital — Norwich, United Kingdom
Full record on ClinicalTrials.gov
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