NEUROprotection Via optimizINg Cerebral Blood Flow afTer cArdiaC arresT (NEURO-INTACT) Study

Recruiting now · Not applicable

Conditions studied: Out-Of-Hospital Cardiac Arrest (OHCA)

In brief

This single-center proof of concept study aims to assess the efficacy of a blood pressure strategy targeting person- and time-specific cerebral blood flow compared with standard-of-care using neuron-specific enolase as a quantitative biomarker of brain injury. Our central hypothesis is that an individualized blood pressure strategy targeting cerebral perfusion will reduce the extent of brain injury as indicated by changes in levels of neuron-specific enolase from baseline at 72 hours. To test this hypothesis, we will recruit 49 patients to an individualized blood pressure management strategy targeting cerebral blood flow, where optimal blood pressure will be serially calculated by the ICM+ brain monitoring software (Cambridge, UK) using inputs from transcranial Doppler ultrasound and near-infrared spectroscopy.

Key facts

Study ID

NCT05679739

Run by

National University Hospital, Singapore

People needed

49

Starts

2023-08-29

Expected to finish

2026-08-01

Last updated by the study team

2025-05-16

Who can join

Age: 21 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• At least 21 years of age
• Comatose defined as not being able to obey verbal commands and no verbal response to pain after sustained ROSC.

You may not qualify if…

• ≥ 80 years old at time of enrolment
• Pregnant patients
• Limitations of care or life support therapy withdrawn within 24 hours of admission

Where it is running

• National University Heart Centre, Singapore — Singapore, Singapore (enrolling)

Full record on ClinicalTrials.gov

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