Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study

Recruiting now

Conditions studied: CADASIL

In brief

This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID). 575 participants will be enrolled and can expect to be on study for up to 5 years.

Key facts

Study ID

NCT05677880

Run by

University of Wisconsin, Madison

People needed

660

Starts

2022-06-03

Expected to finish

2027-08-01

Last updated by the study team

2026-01-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• History of severe learning disability, intellectual disability, or other neurological disease or event not attributable to CADASIL
• History of serious alcohol or drug abuse within the past year
• Unwilling to undergo NOTCH3 genetic testing if there is no test on file

Where it is running

• University of Washington — Seattle, Washington, United States (enrolling)
• University of California — San Francisco, California, United States (enrolling)
• University of Colorado — Denver, Colorado, United States (enrolling)
• Georgia State University Research Foundation — Atlanta, Georgia, United States (enrolling)
• Loyola University — Chicago, Illinois, United States (enrolling)
• Columbia University — New York, New York, United States (enrolling)
• Oregon Health & Science University — Portland, Oregon, United States (enrolling)
• Brown University — Providence, Rhode Island, United States (enrolling)
• University of Utah — Salt Lake City, Utah, United States (enrolling)
• University of California — Los Angeles, California, United States (enrolling)
• University of Texas Health Science Center — Houston, Texas, United States
• University of Texas — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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