Assessment of Occult Lung Stress During Lung Protective Mechanical Ventilation

Withdrawn before enrolling · Not applicable

Conditions studied: Acute Respiratory Distress Syndrome

In brief

The present study will utilize esophageal manometry to measure the presence and magnitude of persistent patient effort during lung protective ventilation, allowing identification and mitigation of occult lung stress.

Key facts

Study ID

NCT05675696

Run by

NYU Langone Health

People needed

0

Starts

2024-10-01

Expected to finish

2025-06-01

Last updated by the study team

2025-04-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Intubated with a diagnosis of ARDS and expected to be ventilated for ≥ 48 hours
• Meets Berlin criteria for ARDS, with or without underlying chronic lung disease
• Triggering breaths on the ventilator
• Treating medical team agrees with patient participation

You may not qualify if…

• Known or suspected esophageal abnormalities, craniofacial abnormalities, or upper GI bleed
• Shock that requires ≥ 2 vasopressors
• pH on arterial blood gas ≤7.25
• Minute ventilation ≥ 14L/min
• Known or suspected pneumothorax, pneumomediastinum, and/or subcutaneous emphysema
• Severe ARDS with P/F ratio <60
• Pregnancy
• Currently receiving extracorporeal membrane oxygenation (ECMO) therapy
• Decision to withhold life-sustaining treatment
• Patients who are not expected to survive for 24 hours
• Lack of informed consent

Where it is running

• Tisch Hospital — New York, New York, United States

Full record on ClinicalTrials.gov

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