A Study of Pressure Waveform Analysis in Coronary Artery-II

Recruiting now

Conditions studied: Ischemic Heart Disease

In brief

The goal of this observational study is to test the feasibility of intracoronary adenosine administration during coronary flow reserve(CFR) and index of microcirculatory resistance(IMR) assessment in a population with angina. The main questions it aims to answer are: * Repeatability of CFR and IMR assessment while hyperemia with intracoronary adenosine was administered. * Evaluate the correlation of the intrinsic signal of coronary waveform versus physiologic ischemia, while defined by fractional flow reserve(FFR) and CFR respectively. * The predictive value of FFR, CFR, and IMR on major adverse cardiovascular outcomes in 3 years Participants will undergo FFR, CFR, and IMR assessments in the catheterization laboratory of the National Taiwan University Hospital Hsin-Chu Branch, then clinical events follow up for 3 years.

Key facts

Study ID

NCT05672706

Run by

National Taiwan University Hospital Hsin-Chu Branch

People needed

30

Starts

2023-01-04

Expected to finish

2027-12-31

Last updated by the study team

2023-01-05

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants with angina

You may not qualify if…

• Severe valvular heart disease
• History of asthma
• Heart rate less than 50 beats per minute
• systolic blood pressure less than 90 mmHg

Where it is running

• National Taiwan University Hospital Hsin-Chu branch — Hsinchu, Taiwan (enrolling)

Full record on ClinicalTrials.gov

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