Sonographic Diaphragm Function in AECOPD

Recruiting now

Conditions studied: Copd

In brief

The study will be conducted as a single-center, prospective cohort study. The primary objective of this study is to investigate the responsiveness of sonographic parameters of diaphragm to detect change in Borg score for dyspnea during hospitalisation for AECOPD without respiratory acidosis.

Key facts

Study ID

NCT05671198

Run by

Isala

People needed

51

Starts

2023-03-27

Expected to finish

2025-08-01

Last updated by the study team

2024-10-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Hospitalisation primarily because of severe acute exacerbation of COPD
• COPD, according to GOLD 2018 definition
• Post-bronchodilator FEV1/FVC < 0,70 and FEV1% < 80%pred. within last 5 years

You may not qualify if…

• Respiratory acidosis (pH < 7.35 ánd PaCO2 > 6 kPA)
• Need for (non-)invasive ventilation based on other criteria (e.g. severe hypoxia) upon presentation.
• Established diagnosis of diaphragm diaphragm paralysis.
• Inability for diaphragm imaging (e.g. mechanical ventilation, or unable to follow vocal instructions).
• Those not able or unwilling to give written informed consent.
• Pregnant women

Where it is running

• Isala Klinieken — Zwolle, Overijssel, Netherlands (enrolling)

Full record on ClinicalTrials.gov

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