Pharmacokinetics of Advantage Arrest in Healthy Children 13-Months to 13-Years of Age

Completed · Phase 2

Conditions studied: Dental Caries in Children

In brief

The purpose of this study is to further characterize basic pharmacokinetic (PK) parameters in healthy children to contribute to evidence for the safety of silver diamine fluoride (SDF; Advantage Arrest). Children with at least one active cavity will be treated and then have blood draws at random time points afterwards.

Key facts

Study ID

NCT05670743

Run by

Advantage Silver Dental Arrest, LLC

People needed

23

Starts

2023-03-01

Expected to finish

2024-08-01

Last updated by the study team

2024-08-06

Who can join

Age: 1 and older, up to 13. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• At least one untreated caries lesion into the dentin
• Live within 10 miles of study site

You may not qualify if…

• oral mucositis
• ulcerative oral lesions
• hypersensitivity to silver or fluoride
• history of treatment with silver diamine fluoride within 3 months

Where it is running

• Center for Pediatric Dentistry — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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