Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

Recruiting now · Phase 4

Conditions studied: Hiv, Opioid Use Disorder

In brief

The investigators will conduct an optimization trial among N=256 PWID newly started on medication for opioid use disorder and Pre-Exposure Prophylaxis (PrEP) to assess the performance of four intervention components (Attention, Executive Functioning, Memory, and Information Processing) aimed at enhancing the ability of PWID on MOUD to process and utilize HIV prevention content, leading to improvements in HIV prevention information, motivation, behavioral skills, and behaviors (IMB).

Key facts

Study ID

NCT05669534

Run by

University of Connecticut

People needed

256

Starts

2023-03-01

Expected to finish

2027-01-01

Last updated by the study team

2026-06-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• being 18 years or older
• meeting DSM-V criteria for opioid dependence and being newly prescribed and adherent to Medication for Opioid Use Disorder (e.g., methadone, buprenorphine) at the APT Foundation, Inc.
• showing mild cognitive impairment based on the Montreal Cognitive Assessment (MoCA) screening
• having initiated Pre-Exposure Prophylaxis (PrEP) within the past week
• confirming HIV-negative status through proof of PrEP prescription
• reporting unsafe injection drug use practices or unprotected sex within the past 3 months
• having a cell phone
• being able to read and understand in English

You may not qualify if…

• unable to provide consent
• actively suicidal
• actively homicidal
• actively psychotic
• display MoCA scores suggestive of dementia

Where it is running

• APT Foundation — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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