A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)
Running, not enrolling · Phase 1/Phase 2
Conditions studied: Cystic Fibrosis
In brief
The purpose of this study is to evaluate the safety, and tolerability and efficacy of VX-522 in participants 18 years of age and older with cystic fibrosis and a cystic fibrosis transmembrane conductance regulator (CFTR) genotype not responsive to CFTR modulator therapy.
Key facts
- Study ID
- NCT05668741
- Run by
- Vertex Pharmaceuticals Incorporated
- People needed
- 26
- Starts
- 2023-02-27
- Expected to finish
- 2026-09-09
- Last updated by the study team
- 2026-05-22
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama at Birmingham - Child Health Research Unit — Birmingham, Alabama, United States
- Memorial Health Services on behalf of Long Beach Memorial Medical Center d/b/a Miller Children's Hospital Long Beach — Long Beach, California, United States
- Stanford University - Palo Alto - Pulmonology — Palo Alto, California, United States
- National Jewish Health — Denver, Colorado, United States
- Clinical & Translational Science Unit (CTSU) - Pulmonology — Kansas City, Kansas, United States
- PAREXEL International - Baltimore — Baltimore, Maryland, United States
- The Johns Hopkins University - Johns Hopkins Hospital - Pulmonology — Baltimore, Maryland, United States
- MGH - MGfC Pediatric Cystic Fibrosis Center — Boston, Massachusetts, United States
- Boston Children's Hospital — Boston, Massachusetts, United States
- University of Minnesota -Pulmonology — Minneapolis, Minnesota, United States
- St. Louis Children's Hospital - Pulmonology — St Louis, Missouri, United States
- UC Health Holmes Hospital — Cincinnati, Ohio, United States
- Medical University of South Carolina - Pulmonology — Charleston, South Carolina, United States
- University of Utah Hospital - Pulmonology — Salt Lake City, Utah, United States
- The Alfred Hospital - Pulmonology — Melbourne, Australia
- Universitair Ziekenhuis Gent — Ghent, Belgium
- University of Calgary Medical Clinic of the Foothills Medical Centre — Calgary, Canada
- IUCPQ Pavillon Recherche U-1771 — Québec, Canada
- Ruhrlandklinik — Essen, Germany
- Karolinska University Hospital - Pulmonology — Stockholm, Sweden
- Papworth Hospital NHS Foundation Trust — Cambridge, United Kingdom
- Queen Elizabeth University Hospital - Pulmonology — Glasgow, United Kingdom
- Royal Brompton Hospital — London, United Kingdom
- Wythenshawe Hospital - OPD — Manchester, United Kingdom
- All Wales Adult Cystic Fibrosis Centre, University Hospital Llandough — Penarth, United Kingdom
Full record on ClinicalTrials.gov
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