Evaluation and Further Development of an Artificial Intelligence-based Algorithm for Clinical Decision Support
Recruiting now
Conditions studied: Invasive Mechanical Ventilation
In brief
Invasive mechanical ventilation is one of the most important and life-saving therapies in the intensive care unit (ICU). In most severe cases, extracorporeal lung support is initiated when mechanical ventilation is insufficient. However, mechanical ventilation is recognised as potentially harmful, because inappropriate mechanical ventilation settings in ICU patients are associated with organ damage, contributing to disease burden. Studies revealed that mechanical ventilation is often not provided adequately despite clear evidence and guidelines. Variables at the ventilator and extracorporeal lung support device can be set automatically using optimization functions and clinical recommendations, but the handling of experts may still deviate from those settings depending upon the clinical characteristics of individual patients. Artificial intelligence can be used to learn from those deviations as well as the patient's condition in an attempt to improve the combination of settings and accomplish lung support with reduced risk of damage.
Key facts
- Study ID
- NCT05668637
- Run by
- Technische Universität Dresden
- People needed
- 318542
- Starts
- 2023-01-01
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2026-04-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects who are 18 years or older and receive invasive mechanical ventilation for > 4 hours
You may not qualify if…
- Patients receiving one-lung ventilation
Where it is running
- Cleveland Clinic Foundation, Cleveland, USA — Cleveland, Ohio, United States (enrolling)
- University Hospital Carl Gustav Carus Dresden — Dresden, Germany (enrolling)
- Institut Fur Angewandte Informatik (Infai) Ev — Leipzig, Germany
- Institut Mihajlo Pupin — Belgrade, Serbia
- Better Care Sl — Sabadell, Spain
- Fundacio Parc Tauli — Sabadell, Spain
- Fundacion Publica Andaluza Progreso Y Salud — Seville, Spain
- Inselspital, Universitätsspital Bern — Bern, Switzerland
Full record on ClinicalTrials.gov
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