A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Primary Generalized Tonic-Clonic Seizures
In brief
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of XEN1101 administered as adjunctive treatment in primary generalized tonic-clonic seizures (PGTCS).
Key facts
- Study ID
- NCT05667142
- Run by
- Xenon Pharmaceuticals Inc.
- People needed
- 160
- Starts
- 2023-02-14
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-07-08
Who can join
Age: 12 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mid-Atlantic Epilepsy and Sleep Center — Bethesda, Maryland, United States (enrolling)
- University of Alabama - Strada Patient Care Center, Neurology — Mobile, Alabama, United States (enrolling)
- University of Maryland Medical Center — Baltimore, Maryland, United States (enrolling)
- MedStar Franklin Square Medical Center — Baltimore, Maryland, United States (enrolling)
- University of California, Irvine - Health Neurology Services — Orange, California, United States (enrolling)
- University of Arizona - Health Science Center — Tucson, Arizona, United States (enrolling)
- University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States (enrolling)
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States (enrolling)
- Serenity Research Center, LLC — Miami, Florida, United States (enrolling)
- Xenoscience — Phoenix, Arizona, United States (enrolling)
- Panhandle Research and Medical Clinic — Pensacola, Florida, United States (enrolling)
- Medsol Clinical Research Center Harbor Professional Centre — Port Charlotte, Florida, United States (enrolling)
- University of South Florida — Tampa, Florida, United States (enrolling)
- Encore Medical Research of Weston, LLC — Weston, Florida, United States (enrolling)
- Emory Brain Health Center — Atlanta, Georgia, United States (enrolling)
- Children's Healthcare of Atlanta — Atlanta, Georgia, United States (enrolling)
- Mayo Clinic Florida — Jacksonville, Florida, United States (enrolling)
- Hawaii Pacific Neuroscience, Comprehensive Epilepsy Center — Honolulu, Hawaii, United States (enrolling)
- Consultants in Epilepsy and Neurology, PLLC — Boise, Idaho, United States (enrolling)
- Southern Illinois University School of Medicine — Springfield, Illinois, United States (enrolling)
- Brain Science Research Institute — Los Angeles, California, United States (enrolling)
- University of Kansas Medical Center — Kansas City, Kansas, United States (enrolling)
- Bluegrass Epilepsy Research, LLC — Lexington, Kentucky, United States (enrolling)
- University of Kentucky Albert B. Chandler Hospital (UK Healthcare) — Lexington, Kentucky, United States (enrolling)
- Medstar Georgetown University Hospital — Clinton, Maryland, United States (enrolling)
Full record on ClinicalTrials.gov
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