R-3750 in Patients With Mild to Moderate Ulcerative Colitis

Recruiting now · Phase 1

Conditions studied: Ulcerative Colitis Chronic Mild, Ulcerative Colitis Chronic Moderate, Ulcerative Colitis Chronic, Ulcerative Colitis

In brief

The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-3750) in patients with mild to moderate ulcerative colitis. Patients will take an oral dosage of probiotic (R-3750) and provide patient-reported and physician scored measures of their colitis. Blood and fecal evaluations of inflammation and assessment of probiotic (R-3750) on fecal levels will also be measured.

Key facts

Study ID

NCT05666960

Run by

Rise Therapeutics LLC

People needed

36

Starts

2023-02-27

Expected to finish

2026-10-01

Last updated by the study team

2026-06-12

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-65 years of age
• Ability to provide written informed consent
• Confirmed diagnosed with UC by colonoscopy and histology and suffering from mild to moderate UC as defined by MMDAI with score of 3-9
• On a stable dose of aminosalicylate (i.e. no change in medication within 4 weeks of study enrollment) and not planning to initiate new medication other than the study drug
• For women of childbearing potential or men with a partner of childbearing potential, agree to use birth control methods (including hormonal contraceptives, intrauterine device (IUD) or hormone releasing system (IUS), vasectomy) and men will refrain from donating sperm during the study and at least 30 days after dosing (per FDA guidelines)
• For the expansion cohort, a flexible sigmoidoscopy is required, unless an endoscopy was completed within 3 months from enrollment is available
• Refrain from receiving any type of vaccinations during the study period (to include but not limited to influenza, COVID, shingles, tetanus, hepatitis, pneumonia, HPV, DPT, MMR, and polio)

You may not qualify if…

• Pregnancy, planned pregnancy, breastfeeding women
• Evidence of severe UC disease (MMDAI score greater than or equal to 10)
• Evidence of any active or recent infection including chronic infectious disease such as Hepatitis B, C, or HIV
• Evidence of any active or recent chronic chest infection with bronchiectasis or sinusitis, or covid-19 infection in the past 3 months
• Treatment with immunosuppressants or anti-cancer drugs, e.g., anti-TNF-α agents, anti-integrin agents, azathioprine or 6-MP, 6-thioguanine, methotrexate, ozanimod, tofacitinid, upadacitinib, tacrolimus, cyclophosphamide, or cyclosporine or any other therapy that is not an aminosalicylate within the last 3 months
• Received an investigational drug within 3 months (or 5 half-lives, whichever is longer) before study entry
• Use of steroidal drugs to treat UC (e.g., prednisone >20 mg/day)
• Use of probiotics within the last one (1) week and during the trial.
• Treatment with systemic broad-spectrum antibiotics in the past 2 months
• Major active systemic autoimmune disease other than UC
• History of anaphylaxis or allergies to probiotics
• History of alcohol or drug abuse within the past 2 years
• History of stroke, or any cerebrovascular disease requiring medication/treatment
• History of cancer, apart from successfully treated basal cell carcinoma or in situ carcinoma of the cervix >1 year prior to enrollment
• Significant laboratory abnormalities, including liver transaminases (AST or ALT) > 1.5X the upper limit of normal.
• Second degree or higher heart block or clinically significant arrythmia
• Any other clinically significant renal, hepatic, hematological or other disease or laboratory abnormality which, in the opinion of the investigator, would interfere with the conduct, the interpretation of the safety signals or results of the trial, or would place the subject at unacceptable risk
• Any condition or circumstance that, in the opinion of the Principal Investigator, would compromise the safety of the subject or the quality of study data

Where it is running

• Amicis Research Center — Valencia, California, United States (enrolling)
• AP Medical Research LLC — Miami, Florida, United States (enrolling)
• Edward Jenner Research Group, LLC — Plantation, Florida, United States (enrolling)
• Adtremed Research Clinic — Tampa, Florida, United States (enrolling)
• Mayo Clinic — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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