Concurrent TMS and EEG Pilot Study
Completed · Not applicable
Conditions studied: Healthy
In brief
This study will investigate the test-retest reliability of transcranial magnetic stimulation (TMS) -evoked potentials (TEPs) as measured by electroencephalography (EEG), using three different TMS protocols over five different brain regions in healthy volunteers. The goal is to compare the test-retest reliability of single pulse, inhibitory and excitatory TMS protocols as well as two distinct targeting approaches. The main questions to answer are: 1. This study will investigate whether the test-retest reliability of TEPs differ across TMS protocols. 2. This study will investigate whether the test-retest reliability of TEPs differ between individualized and non-individualized targeting approaches.
Key facts
- Study ID
- NCT05665634
- Run by
- Johns Hopkins University
- People needed
- 24
- Starts
- 2022-12-02
- Expected to finish
- 2023-11-20
- Last updated by the study team
- 2024-01-22
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Medically and psychiatrically healthy
- Between the ages of 18 and 65 years old
- Fluent in English and capable of providing informed consent
- Willing to remove any jewelry, hair clips, bobby pins, or any other potentially conducting or magnetic objects worn on or near the head
You may not qualify if…
- Weight greater than 350 lbs (the weight limit of the specialized TMS/EEG chair)
- Current serious medical or psychiatric illness, or recent heart disease
- Acute intoxication with any drug of abuse, including alcohol or cannabis
- Pregnancy
- History of neurological problems, including epilepsy, seizures, syncope, tinnitus, migraine, or frequent non-migraine (e.g. tension) headaches
- History of head trauma associated with loss of consciousness
- Language or hearing impairment that would undermine communication regarding consent, study procedures, and overall volunteer safety.
- Irritable skin
- For those undergoing MRI procedures in the current study: Any standard MRI contraindication (including implanted medical devices, metal in the body, or claustrophobia incompatible with MRI procedures)
- TMS-contraindicated medical devices, including cochlear implants, pacemaker, neurosensory stimulator, implantable defibrillator, insulin pump, clips, stents, or shunts that may be disrupted by or interact with TMS coil operation
- Taking medications that lower seizure threshold (see Appendix A: List of Contraindicated Medications)
Where it is running
- Johns Hopkins Medicine — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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