Laryngeal Cryotherapy for Refractory Neurogenic Cough

Recruiting now

Conditions studied: Upper-Airway Cough Syndrome

In brief

This study aims to evaluate the safety and efficacy of upper aerodigestive tract cryotherapy treatment in patients with refractory neurogenic cough in a prospective pilot study with a validated patient reported outcome measure

Key facts

Study ID: NCT05665244
Run by: University of Texas Southwestern Medical Center
People needed: 28
Starts: 2022-12-26
Expected to finish: 2027-02-01
Last updated by the study team: 2026-01-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adult patients 18 years or older with diagnosis of neurogenic cough
Neurogenic cough is a diagnosis of exclusion applied to persistent cough (8 weeks or longer)
Negative workup for other causes, including sinonasal allergies/chronic sinusitis, cough-variant asthma, and GERD
Patient willing to participate in a clinical trial

You may not qualify if…

Uncontrolled reflux (scoring on Reflux Symptom index of 13 or higher)
Vocal fold abnormalities or impairment
History of asthma or other underlying lung condition not adequately treated or controlled
Uncontrolled Allergic Rhinitis (Total Nasal Symptom Score >6, which would indicate moderate disease32)
Reported symptom of postnasal drip
Current smoker
Current neuromodulator medication use
Patient unwilling to participate in clinical trial or sign an informed consent
End stage medical disease with poor life expectancy
Medical instability deemed by the investigators as a contraindication for enrollment
Abnormal Chest X-ray
Abnormal pulmonary function testing (PFTs)
Positive local allergy panel (combined RAST testing)

Where it is running

UT Southwestern Medical Center — Dallas, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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