Autonomic Effects of Stimulation in SCI

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: Spinal Cord Injury

In brief

This study aims to determine the effects of transcutaneous spinal cord stimulation to increase blood pressure and use that device to increase power output and heart rate recovery during arm cycle ergometry. In addition, the investigators will see if the stimulation helps regulate body temperature when in a cool environment.

Key facts

Study ID

NCT05664646

Run by

VA Office of Research and Development

People needed

20

Starts

2023-07-24

Expected to finish

2026-07-30

Last updated by the study team

2026-07-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• injury more than 1 year ago, non-ambulatory
• level of lesion C3-T6, AIS A, B, or C
• stable prescription medication regimen for at least 30 days
• must be able to commit to study requirements of 7 visits within a 60-day period

You may not qualify if…

• extensive history of seizures
• ventilator dependence or patent tracheostomy site
• history of neurologic disorder other than SCI
• history of moderate or severe head trauma
• contraindications to spine stimulation
• significant cardiovascular disease
• active psychological disorder
• recent history (within 3 months) of substance abuse
• open skin lesions over spine at levels targeted for stimulation (L1/L2) and pregnancy

Where it is running

• James J. Peters VA Medical Center, Bronx, NY — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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